learn/steps in the work
Acquisition
Acquisition is the first step in any study: getting hold of the raw data, whether by taking a measurement, running an instrument, downloading a public archive or pulling records out of a database.
What it is
Every piece of research begins with something to work on. Acquisition is the act of obtaining that raw material. Sometimes it means making a measurement: pointing a telescope at the sky, recording a signal from a detector, running a chemical reaction and recording what comes out. Sometimes it means retrieval instead: downloading files from a public repository, copying records out of a database, or gathering published papers. The word covers both, because what matters is not the method but the result, which is data that did not exist in the researcher's hands before and now does.
Raw data is rarely tidy. It arrives in whatever form the instrument or archive produces: images, spectra, time series, text, long tables of numbers. Acquisition stops at that point. Deciding what to keep, correcting for faults, converting units and arranging things into a usable table all come later, and are usually treated as separate steps. Keeping acquisition distinct matters because it is the step that fixes what is possible: nothing can be analysed that was never obtained, and a flaw introduced here is carried through everything that follows.
Why scientists use it
Scientists separate out acquisition because it is where the questions of coverage and bias are settled. If a telescope only looks at part of the sky, or an archive only holds molecules that someone thought worth depositing, every later conclusion inherits that narrowness. Writing the step down makes those choices visible and lets other people judge or repeat them.
The step has grown more important as machine learning has spread through the sciences. These methods learn patterns from many examples rather than following rules written by hand, so they need large amounts of data, and their quality tracks the quality of what they were given. That has pushed researchers towards instruments and robots that acquire data continuously, and towards mining archives and published literature for material that was gathered for other purposes. Acquisition in that setting stands in for the older, slower business of a person running one experiment at a time.
In the record
Limits
Acquisition says nothing about whether the data is any good. An instrument can be miscalibrated, an archive can be skewed towards whatever was easy or fashionable to collect, and a download can be large while still missing the cases that matter. Volume is especially misleading: a great many measurements of nearly the same thing carry little more information than a few. Nor does obtaining data make it usable. Raw output often needs heavy correction before it means anything, and some of it will simply be discarded.
Written by AIxSci: the background from general knowledge, the examples from checked records.
Every article
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Machine learning predicts where dopant atoms sit in hexaferrite crystals before refinement
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Neural networks sort millions of stars to build a young-star candidate catalogue
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Software reads AlphaFold predictions to infer how protein complexes assemble
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Deep learning model flags bacterial proteins likely to drive infection
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Machine learning predicts galaxy 'relicness' from survey measurements, cutting spectroscopy demand
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Neural network supplies the sideways flows needed to measure the quiet Sun's magnetic energy
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Neural network predicts how titanium alloy grains round off during annealing
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Neural network measures rotation periods for Kepler's main-sequence stars
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Machine learning sifts a million candidate moving objects to find 258 new cool stars
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Random forest sorts 130 million Magellanic Cloud sources into ten classes
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Classifiers label individual TESS brightness readings as planet transits or not
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Neural network ranks gravitational wave triggers in search for neutron star mergers
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Neural networks predict how much ultrasound energy drives magnesia dissolution
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Neural network trained on survey data retuned to spot transients for a liquid mirror telescope
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Image classifiers flag a gas kink in a young star's disc, pointing to a planet
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Astronomers map the mass of galaxy cluster Abell 2744 using lensed images
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Neural network turns Kaguya camera images into global maps of lunar surface chemistry
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Neural network predicts atomic charges from bond lists, without atomic coordinates
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Machine learning fitted to flexible molecules predicts oxidation potentials and hydration energies
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Researchers read an AlphaFold model of honey bee vitellogenin's tail end
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Machine learning assigns atomic charges to size up polarisation in bismuth vanadate conductors
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Structure predictions place an uncharacterised human protein in the BRICHOS family
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Microscopy and a trained classifier map which E. coli proteins clump together
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Protein language model and two classifiers predict where ATP binds on proteins
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Neural network predicts crystal density of candidate explosives from molecular structure
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AlphaFold models used to map membrane-crossing segments in human proteins
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Neural networks pick amino acid sequences for short peptides in protein binding sites
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Neural networks trained to find the cutting site on serpin proteins
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Classifier sorts true from false AlphaFold predictions of human protein pairs
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Deep learning sorts crystal structures for single-molecule magnet behaviour
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Testing whether symmetry-aware neural networks can tell apart atomic arrangements in perovskites
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Software splits coiled-coil proteins into short windows for AlphaFold to model
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Peptides designed by simulation and machine learning sit at condensate surfaces
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Thin molybdenum disulfide memory cells tested, with reinforcement learning fitting their circuit model
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Neural network assigns protein domains to structural families from sequence alone
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Neural network scans eleven years of night-sky images for mesospheric wave fronts
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Deep learning reads cryo-EM maps alongside AlphaFold3 models to build protein structures
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AlphaFold's confidence scores used to predict which disordered protein segments bind LC8
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Neural network fills gaps in protein maps from raw diffraction data
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Machine learning tested against three definitions of protein shape-shifting
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Machine learning ranks stable materials by predicted superconducting temperature
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Machine-learned potentials trained to simulate copper ion conductor Cu7PS6 faster
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Software models of two cancer proteins used to rank mutations by likely effect
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Model labels which protein residues are active sites and what job they do
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Robot laser-heats thin films while software picks each next heating condition
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AI-labelled protein pairs used to test how well function predictors handle unknown proteins
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Diffusion model generates synthetic images of the Sun sorted by flare strength
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Machine learning predicts nanofibre thickness from electrospinning settings, tested against new scaffolds
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Simulations probe shape-shifting of opium poppy's reticuline-flipping enzyme using a predicted structure
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Neural network potentials trained by repeatedly checking where models disagree on hydrogen sticking to copper
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Machine learning picked catalyst recipes for a loop of 44 lab cycles
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Clustering algorithm sorts cluster stars from background stars in thirteen open clusters
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Meta-learning lets a cosmology emulator adapt to new galaxy depth maps quickly
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Regression models predict how graphene loading changes aluminium's electron emission
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Five codes measured galaxy shapes in simulated Euclid images, one using neural networks
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Machine-learned potential predicts how chromium sulfide layers rearrange during exfoliation
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Machine-learned potential makes long simulations of CO hydrogenation on rhodium affordable
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Neural network predicts protein pair binding strength from simplified molecular models
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Protein language model embeddings used to predict succinylation sites in proteins
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Neural network predicts nanostructure optics to design a two-colour laser collimator
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Machine learning scores short protein stretches that mark proteins for destruction
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Protein language model trained to spot lactylated lysines in rice proteins
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Machine-learned force field used to model two crystal forms of formamide
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Machine learning sorts antibody heavy chains by the germ they target
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A transformer model segments cryo-electron tomograms from three viewing directions at once
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Study tests whether AI clean-up of cryo-EM maps harms ligand density
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Researchers train a machine-learned force model to simulate carbon nanotubes' strength and heat limits
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Software predictors compare protein floppiness across retinal disease protein sets
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Random Forest sorts 9,446 white dwarfs by type from Gaia spectra
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Machine learning sorts mitochondrial proteins into three compartments from sequence alone
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Neural networks replace a slow statistical fit to find solar oscillations in Hα images
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Deep learning model predicts polymer heat-softening across 48,208 designed candidates
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Neural network reads protein surfaces to predict DNA and RNA binding
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A compact way to describe molecules speeds up machine learning of their properties
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Random atoms settle into molecules and crystals on a learned energy surface
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Protein language model embeddings tested against classical descriptors for spotting resistance genes
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Machine learning sorts plant protein sequences into disease-resistance proteins or not
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Volunteer labels train a model to find asteroid trails in Hubble archive images
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Neural networks sort 400,000 JWST galaxies to trace when spirals and spheroids appeared
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Astronomers test pre-trained image models for sifting telescope alerts
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Weighing the Milky Way's disk reveals a mass excess along the Local Arm
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Neural networks speed up forecasts of what gravitational wave detections LISA will catch
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Neural networks estimate dark matter halo masses from a galaxy's neighbours
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Neural network potential used to simulate carbon dioxide moving inside porous frameworks
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Neural network predicts gas pressure in galaxy clusters from dark matter alone
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Cryo-EM maps and AlphaFold models explain how two bacterial helper proteins activate an enzyme
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Neural network retrained to predict how crystals absorb light, from few examples
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Neural networks turn simulated cluster mass maps into X-ray and SZ images
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Machine learning sifts three-colour infrared survey data for cold brown dwarfs
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Changing the training penalty improves how a network spots beta-sheets in blurry protein maps
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Neural networks sift 812,118 quasar spectra for hidden gravitational lenses
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Neural network strips mains-power hum from LIGO data in about a second
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Software predictions map floppy stretches of touch-sensing PIEZO channels
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Neural networks sort eleven years of Mars plasma data into three regions
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Attention patterns inside a protein language model used to cut sequences into reusable units
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Neural networks rebuild cosmic expansion history to calibrate gamma-ray burst energies
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Machine learning predicts marine steel corrosion from seawater conditions and alloy make-up
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Machine learning sifts 25,000 known materials for quantum-technology host candidates
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Model predicts how fast an enzyme works on a substrate, with uncertainty attached
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A single neural network stands in for quantum calculations across 45 elements
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A search engine for radio galaxy shapes, built on a fine-tuned image-text model
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Deep-learning model designs petrol blends from octane and soot targets
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Genetic algorithm trims chemical reaction lists for hot Jupiter atmosphere models
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Deep learning tool predicts how single mutations weaken protein partnerships
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Bayesian program merges X-ray diffraction data from three experiment types in one step
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Benchmark measures how well AlphaFold predicts antibody-antigen complex structures
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Machine learning tool flags protein helices likely to bind DNA or RNA
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Software reconstructs supernova spectra and physical properties from brightness measurements alone
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Neural networks stand in for slow galaxy clustering calculations in cosmology analyses
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Two neural networks predict how heat shrinks the band gap of silver-based crystals
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Neural network maps cosmic voids, walls and filaments from sparse galaxy tracers
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Astronomers hunt dust-buried young star clusters in eleven nearby galaxies
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Four million simulated X-ray patterns used to test 21 crystal-symmetry classifiers
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GPT-4 reads band gap values from paper sentences to train better predictors
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Neural network built from physics equations extracts solder deformation coefficients
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Neural network turns galaxy shape distortions into maps of invisible cluster mass
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Keck spectra pin down distances for six gravitational lenses found by a neural network
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Software spotted a nearby supernova and booked a telescope within minutes
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Cryo-EM maps show water shifting in actin filaments as they age
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Machine learning picks a new metal mixture, which casting and X-rays confirm
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Software works out protein shapes from electron microscope images using statistics
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Neural network reads a million star spectra to measure temperature and chemistry
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Neural network sorts six hundred thousand noise blips in LIGO gravitational-wave data
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Neural network picks bright exploding stars from sky survey alerts and books telescope time
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Machine learning picked which shape-memory alloys to make next, round by round
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Transformer model predicts how gas-storing crystals take up gases, replacing slow simulations
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Neural network segments 650 battery particles to measure their detachment after cycling
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Machine-learned force model simulates silicon-oxygen structures from glass surfaces to monoxide grains
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Robotic lab with machine learning proposes and runs 353 inorganic synthesis experiments
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Protein shapes computed from patterns of change across families of related sequences
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Cryo-tomography maps the myosin filament inside relaxed mouse heart muscle
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Researchers map the sixteen-part Commander complex using crystals, cryo-EM and AlphaFold2
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Deep learning turns raw NMR spectra into protein structures without human intervention
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